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Jeong, Jaepil; Szczepaniak, Grzegorz; Yerneni, Saigopalakrishna S.; Lorandi, Francesca; Jafari, Hossein; Lathwal, Sushil; Das, Subha R.; Matyjaszewski, Krzysztof (, Chemical Communications)Sodium pyruvate, a natural intermediate produced during cellular metabolism, is commonly used in buffer solutions and media for biochemical applications. Here we show the use of sodium pyruvate (SP) as a reducing agent in a biocompatible aqueous photoinduced azide–alkyne cycloaddition (CuAAC) reaction. This copper( i )-catalyzed 1,3-dipolar cycloaddition is triggered by SP under UV light irradiation, exhibits oxygen tolerance and temporal control, and provides a convenient alternative to current CuAAC systems, particularly for biomolecular conjugations.more » « less
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Szczepaniak, Grzegorz; Fu, Liye; Jafari, Hossein; Kapil, Kriti; Matyjaszewski, Krzysztof (, Accounts of Chemical Research)null (Ed.)
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